Division of
Professional Regulation

Controlled Substances Registration – Advanced Practice Registered Nurse

These instructions apply only to Advanced Practice Registered Nurses.

General Information

  • If you don’t already have prescriptive authority when you file this CSR application, you should receive your CSR 3-4 weeks after your prescriptive authority is approved.  Please allow the 3-4 weeks to elapse before calling the office.
  • Your Delaware CSR certificate and all CSR-related correspondence must be mailed to the same address as your APRN license.
  • You need a Delaware CSR to prescribe or to store/dispense controlled substances in Delaware.  Even if you have a CSR or DEA registration in another jurisdiction, you still need a Delaware CSR to prescribe or to store/dispense controlled substances in Delaware.
  • You need only one Delaware CSR to prescribe controlled substances in Delaware even if you prescribe controlled substances at more than one Delaware business/practice or more than one location of a business/practice.  However, every Delaware location where controlled substances are dispensed/stored must be covered by a CSR.  If no other practitioner (e.g., physician), physician assistant or APRN holds a Delaware CSR for a location where you will store/dispense, as well as prescribe, controlled substances, you must file for an additional CSR for the location in Question 12 of the application.
  • When your Delaware CSR is approved, you must file for a federal DEA registration for Delaware. You must have both a Delaware CSR and DEA registration for Delaware before prescribing controlled substances in Delaware.  A DEA registration in another jurisdiction is not sufficient for prescribing controlled substances in Delaware.


Requirements for All Applicants

  • Enclose the non-refundable processing fee by check or money order made payable to “State of Delaware.”  The total fee depends on how many CSRs you are applying for.  Multiply the fee on the Fee Schedule by the number of registrations applied for in Question 2 of the application (not the controlled substance schedule in Question 6).
  • Complete the one-hour Mandatory Course training on Delaware law, regulation and programs on prescribing and distribution of controlled substances.

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